OUR SCIENCE
SMART DRUG DELIVERY PLATFORM BASED ON CELL-DERIVED VESICLES
BioDrone™ Platform
BioDrone™ Platform is a CDV (cell-derived vesicle)-based drug delivery system (DDS). It is a groundbreaking drug delivery platform that selectively delivers various drugs to the specific lesions by loading them on the CDV.
A technology that can be applied to a variety of cells without limitations and that overcomes the productivity limitations of conventional EVs (e.g., exosomes)
Inclusion of biomolecules (RNA/DNA/Protein) and chemicals, etc., in CDV
Effective delivery to specific tissues through a cell source or surface engineering of CDV
Drug loading
A CDV is a drug transporter capable of loading various drugs, including genetic materials such as mRNA, small RNA, and low-molecular-weight compounds. Based on the following two strategies, MDimune is focusing on research into loading various medications.
2 Different Drug Loading Strategies
- Endogenous : enrichment of biomolecular payloads inside the cell, followed by extrusion
- Exogenous : drug encapsulation on purified CDVs
Tissue targeting
It is possible to produce vesicles with enhanced targeting functions using human tissue cells with various functions and specific transformed cells. Based on this, we are developing a drug delivery system with enhanced cancer targeting, brain tissue penetration, and therapeutic efficacy.
2 Different Targeting Strategies
- Endogenous : genetic engineering of cell source
- Exogenous : targeting ligand on CDVs’ membrane surface
